NUS1 Antibody (PACO10978)
- SKU:
- PACO10978
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NUS1 Antibody (PACO10978) |
| Antibody SKU: | PACO10978 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human NUS1 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae);NUS1;C6orf68;MGC117249;MGC7199;MGC:7199;NgBR ; |
| UniProt Protein Function: | Function: Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Ref.5 Ref.7Essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Ref.5 Ref.7Pathway: Protein modification; protein glycosylation.Subunit structure: Interacts with DHDDS, promoting its isoprenyltransferase activity. Interacts with NPC2. Ref.6 Ref.7Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note: Colocalizes with Nogo-B during VEGF and wound healing angiogenesis. Ref.6 Ref.7Miscellaneous: Although strongly related to UPP synthase family proteins, it has no lipid transferase activity.NUS1 seems to exist in two topological orientations, a minor glycosylated species with its C-terminus oriented towards the lumen regulating NPC2 stability, and a major fraction oriented with its C-terminus directed towards the cytosol where it regulates cis-IPTase activity.Sequence similarities: Belongs to the UPP synthase family.Sequence caution: The sequence AAB72234.1 differs from that shown. Reason: Frameshift at several positions. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96E22 |
| NCBI GenInfo Identifier: | 20270243 |
| NCBI Gene ID: | 116150 |
| NCBI Accession: | NP_612468.1 |
| UniProt Secondary Accession: | Q96E22,O00251, B2RWQ4 |
| UniProt Related Accession: | Q96E22 |
| Molecular Weight: | 33,224 Da |
| NCBI Full Name: | nogo-B receptor |
| NCBI Synonym Full Names: | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) |
| NCBI Official Symbol: | NUS1 |
| NCBI Official Synonym Symbols: | NgBR; C6orf68; TANGO14; MGC:7199 |
| NCBI Protein Information: | nogo-B receptor; transport and golgi organization 14 homolog |
| UniProt Protein Name: | Nogo-B receptor |
| UniProt Synonym Protein Names: | Nuclear undecaprenyl pyrophosphate synthase 1 homolog |
| Protein Family: | Dehydrodolichyl diphosphate synthase complex |
| UniProt Gene Name: | NUS1 |
| UniProt Entry Name: | NGBR_HUMAN |
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