NS1 Antibody (PACO61846)
- SKU:
- PACO61846
- Product Type:
- Antibody
- Reactivity:
- Virus
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NS1 Antibody (PACO61846) |
| Antibody SKU: | PACO61846 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human parvovirus B19 |
| Immunogen: | Recombinant Human parvovirus B19 Non-capsid protein NS-1 protein (1-255AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in Recombinant protein. All lanes: NS1 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 45 kDa. Observed band size: 45 kDa. |
| Background: | Seems necessary for viral DNA replication. |
| Synonyms: | Non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1), NS1 |
| UniProt Protein Function: | Multifunctional protein essential for viral DNA replication, which cooperatively interacts with the viral DNA origin of replication and transactivates several promoters including the viral p6 promoter. Binds the origin of replication and performs an endonucleolytic nick within a conserved sequence in the viral genome, thereby initiating the rolling circle replication (RCR). Participates in the transcriptional regulation the viral p6 promoter that regulates all viral transcripts and the cellular CDN1A or IL6 promoters. Transactivates several host promoters some of which induce the S cell cycle phase for the production of host replicative proteins. Upregulates the expression of host E2F4 and E2F5 and interacts with both these factors thereby inhibiting the host cell cycle G2/M transition. This arrest promotes apoptosis for viral release. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P07298 |
| NCBI GenInfo Identifier: | 138881 |
| NCBI Gene ID: | |
| NCBI Accession: | P07298.1 |
| UniProt Secondary Accession: | P07298 |
| UniProt Related Accession: | P07298 |
| Molecular Weight: | |
| NCBI Full Name: | Initiator protein NS1 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Initiator protein NS1 |
| UniProt Synonym Protein Names: | NCVP1; Non-capsid protein NS-1; Non-structural protein 1; Non-structural protein NS1 |
| Protein Family: | Non-capsid protein |
| UniProt Gene Name: | NS1 |
| UniProt Entry Name: |
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