NS Antibody (PACO61854)
- SKU:
- PACO61854
- Product Type:
- Antibody
- Reactivity:
- Virus - Influenza A
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NS Antibody (PACO61854) |
| Antibody SKU: | PACO61854 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Influenza A virus |
| Immunogen: | Recombinant Influenza A virus Non-structural protein 1 protein (1-237AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in Recombinant protein. All lanes: NS antibody at 5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 32 kDa. Observed band size: 32 kDa. |
| Background: | Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. |
| Synonyms: | Non-structural protein 1 (NS1) (NS1A), NS |
| UniProt Protein Function: | Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q0HD54 |
| NCBI GenInfo Identifier: | 123870362 |
| NCBI Gene ID: | |
| NCBI Accession: | Q0HD54.1 |
| UniProt Secondary Accession: | Q0HD54 |
| UniProt Related Accession: | Q0HD54 |
| Molecular Weight: | 14,452 Da |
| NCBI Full Name: | Non-structural protein 1 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Non-structural protein 1 |
| UniProt Synonym Protein Names: | NS1AUniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_04066 |
| Protein Family: | NSFL1 cofactor |
| UniProt Gene Name: | NS |
| UniProt Entry Name: |
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