NS Antibody (PACO60937)
- SKU:
- PACO60937
- Product Type:
- Antibody
- Reactivity:
- Virus - Influenza A
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NS Antibody (PACO60937) |
| Antibody SKU: | PACO60937 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Influenza A virus |
| Immunogen: | Recombinant Influenza A virus Non-structural protein 1 protein (152-237AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1. In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism. |
| Synonyms: | Non-structural protein 1 (NS1) (NS1A), NS |
| UniProt Protein Function: | Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1. In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P03495 |
| NCBI GenInfo Identifier: | 138921 |
| NCBI Gene ID: | |
| NCBI Accession: | P03495.1 |
| UniProt Secondary Accession: | P03495,Q1K9D5 |
| UniProt Related Accession: | P03495 |
| Molecular Weight: | 14,365 Da |
| NCBI Full Name: | Non-structural protein 1 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Non-structural protein 1 |
| UniProt Synonym Protein Names: | NS1A |
| Protein Family: | Nuclear export protein |
| UniProt Gene Name: | NS |
| UniProt Entry Name: |
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