NRG1 Antibody (PACO23116)

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SKU:
PACO23116
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Applications:
WB
Applications:
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated

Description

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Antibody Name:NRG1 Antibody (PACO23116)
Antibody SKU:PACO23116
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100
Species Reactivity:Human, Mouse, Rat
Immunogen:Synthesized peptide derived from human NRG1 isoform-10.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from SKOV3 cells, using NRG1 isoform-10 antibody.
Product ImageImmunohistochemical analysis of paraffin-embedded human brain tissue using NRG1 isoform-10 antibody.
Background:The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).
Synonyms:Pro-neuregulin-1; membrane-bound isoform; Pro-NRG1; NRG1; GGF
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
UniProt Code:Q15491
NCBI GenInfo Identifier:236463556
NCBI Gene ID:3084
NCBI Accession:NP_001153476
UniProt Secondary Accession:Q15491
UniProt Related Accession:Q15491,Q02297
Molecular Weight:~ 44kDa
NCBI Full Name:pro-neuregulin-1, membrane-bound isoform isoform ndf43b
NCBI Synonym Full Names:neuregulin 1
NCBI Official Symbol:NRG1  
NCBI Official Synonym Symbols:GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; MSTP131; NRG1-IT2  
NCBI Protein Information:pro-neuregulin-1, membrane-bound isoform
UniProt Protein Name:Pro-neuregulin-1, membrane-bound isoform
UniProt Synonym Protein Names:Acetylcholine receptor-inducing activity; ARIA; Breast cancer cell differentiation factor p45; Glial growth factor; Heregulin; HRG; Neu differentiation factor; Sensory and motor neuron-derived factor
Protein Family:
UniProt Gene Name:NRG1  
UniProt Entry Name:NRG1_HUMAN
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