Description
Product Name: | NR1I3 Polyclonal Antibody |
Product Code: | CAB21765 |
Reactivity: | Human, Mouse |
Applications: | Western blotting, Immunofluorescence |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Reactivity: | Human, Mouse |
Tested Applications: | WB, IF/ICC, ELISA |
Key Applications: | Western blotting, Immunofluorescence |
Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
Positive Samples: | Mouse ovary |
Cellular Location: | Cytoplasm, Nucleus, cytoskeleton |
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene.
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 103-352 of human NR1I3 (NP_001070948.1). |
Sequence: | PVQLS KEQEE LIRTL LGAHT RHMGT MFEQF VQFRP PAHLF IHHQP LPTLA PVLPL VTHFA DINTF MVLQV IKFTK DLPVF RSLPI EDQIS LLKGA AVEIC HIVLN TTFCL QTQNF LCGPL RYTIE DGARV SPTVG FQVEF LELLF HFHGT LRKLQ LQEPE YVLLA AMALF SPDRP GVTQR DEIDQ LQEEM ALTLQ SYIKG QQRRP RDRFL YAKLL GLLAE LRSIN EAYGY QIQHI QGLSA MMPLL QEICS |
Synonyms: | CAR, CAR1, MB67 |
Calculated MW: | 40kDa |
Observed MW: | 40kDa |