NR1H2 Polyclonal Antibody
- SKU:
- CAB21754
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | NR1H2 Polyclonal Antibody |
| Product Code: | CAB21754 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:100-1:500, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | PC-3, 3T3-L1 |
| Cellular Location: | Nucleus |
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-260 of human NR1H2 (NP_009052.4). |
| Sequence: | QSQSP VGPQG SSSSA SGPGA SPGGS EAGSQ GSGEG EGVQL TAAQE LMIQQ LVAAQ LQCNK RSFSD QPKVT PWPLG ADPQS R |
| Synonyms: | NER, UNR, LXRB, LXR-b, NER-I, RIP15 |
| Calculated MW: | 51kDa |
| Observed MW: | 63kDa |
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