NQO1 Polyclonal Antibody
- SKU:
- CAB22003
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | NQO1 Polyclonal Antibody |
| Product Code: | CAB22003 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | Hep G2, MCF7 |
| Cellular Location: | cytoplasm, cytosol, dendrite, synapse |
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human NQO1 (NP_000894.1). |
| Sequence: | MVGRR ALIVL AHSER TSFNY AMKEA AAAAL KKKGW EVVES DLYAM NFNPI ISRKD ITGKL KDPAN FQYPA ESVLA YKEGH LSPDI VAEQK KLEAA DLVIF QFPLQ WFGVP AILKG WFERV FIGEF AYTYA AMYDK GPFRS KKAVL SITTG GSGSM YSLQG IHGDM NVILW PIQSG ILHFC GFQVL EPQLT YSIGH TPADA RIQIL EGWKK RLENI WDETP LYFAP SSLFD LNFQA GFLMK KEVQD EEKNK KFGLS VGHHL GKSIP TDNQI KARK |
| Synonyms: | DTD, QR1, DHQU, DIA4, NMOR1, NMORI |
| Calculated MW: | 31kDa |
| Observed MW: | 31kDa |
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