Antibody Name:	Npr3 Antibody (PACO28634)
Antibody SKU:	PACO28634
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Rat
Immunogen:	Recombinant Rat Atrial natriuretic peptide receptor 3 protein (41-477AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity (By similarity).

Synonyms:

Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C), Npr3, Npr-c

UniProt Protein Function:	ANP-C: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. Belongs to the ANF receptor family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, GPCRCellular Component: integral to plasma membrane; membrane; plasma membraneMolecular Function: adenylate cyclase activity; hormone binding; natriuretic peptide receptor activity; peptide hormone binding; peptide receptor activity, G-protein coupled; protein homodimerization activityBiological Process: cAMP-mediated signaling; cyclic nucleotide biosynthetic process; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); negative regulation of adenylate cyclase activity; negative regulation of smooth muscle cell proliferation; pancreatic juice secretion; phosphoinositide-mediated signaling; positive regulation of nitric-oxide synthase activity; regulation of blood pressure; regulation of osteoblast proliferation; skeletal development
UniProt Protein Details:
NCBI Summary:	receptor for natriuretic peptide; may play role in hypertension and neurotransmitter efflux [RGD, Feb 2006]
UniProt Code:	P41740
NCBI GenInfo Identifier:	6981282
NCBI Gene ID:	25339
NCBI Accession:	NP_037000.1
UniProt Secondary Accession:	P41740,Q64156
UniProt Related Accession:	P41740
Molecular Weight:	64.9 kDa
NCBI Full Name:	atrial natriuretic peptide receptor 3
NCBI Synonym Full Names:	natriuretic peptide receptor 3
NCBI Official Symbol:	Npr3
NCBI Official Synonym Symbols:	NPRC; ANP-CR
NCBI Protein Information:	atrial natriuretic peptide receptor 3
UniProt Protein Name:	Atrial natriuretic peptide receptor 3
UniProt Synonym Protein Names:	Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; ANP-C; ANPR-C; NPR-C
Protein Family:	Atrial natriuretic peptide receptor
UniProt Gene Name:	Npr3
UniProt Entry Name:	ANPRC_RAT