NPC2 Antibody (PACO35826)
- SKU:
- PACO35826
- Product Type:
- Antibody
- Reactivity:
- Canine
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NPC2 Antibody (PACO35826) |
| Antibody SKU: | PACO35826 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Dog |
| Immunogen: | Recombinant Dog NPC intracellular cholesterol transporter 2 protein (22-149AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport. |
| Synonyms: | NPC intracellular cholesterol transporter 2 (Epididymal secretory protein E1) (cE1) (Niemann Pick type C2 protein homolog), NPC2 |
| UniProt Protein Function: | Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q28895 |
| NCBI GenInfo Identifier: | 3182994 |
| NCBI Gene ID: | 403920 |
| NCBI Accession: | Q28895.1 |
| UniProt Secondary Accession: | Q28895 |
| UniProt Related Accession: | Q28895 |
| Molecular Weight: | 16 kDa |
| NCBI Full Name: | Epididymal secretory protein E1 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | NPC2 |
| NCBI Official Synonym Symbols: | CE1 |
| NCBI Protein Information: | epididymal secretory protein E1 |
| UniProt Protein Name: | Epididymal secretory protein E1 |
| UniProt Synonym Protein Names: | Niemann Pick type C2 protein homolog; cE1 |
| Protein Family: | Epididymal secretory protein |
| UniProt Gene Name: | NPC2 |
| UniProt Entry Name: | NPC2_CANLF |
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