Antibody Name:	NLRP4 Antibody (PACO20062)
Antibody SKU:	PACO20062
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human
Immunogen:	Synthetic peptide of human NLRP4

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20062(NLRP4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20062(NLRP4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes

Synonyms:

NLR family, pyrin domain containing 4

UniProt Protein Function:	NALP4: May be involved in inflammation. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 19q13.43Cellular Component: cytosolBiological Process: regulation of interferon type I production
UniProt Protein Details:
NCBI Summary:	NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
UniProt Code:	Q96MN2
NCBI GenInfo Identifier:	148887404
NCBI Gene ID:	147945
NCBI Accession:	Q96MN2.3
UniProt Secondary Accession:	Q96MN2,Q86W87, Q96AY6
UniProt Related Accession:	Q96MN2
Molecular Weight:	103,968 Da
NCBI Full Name:	NACHT, LRR and PYD domains-containing protein 4
NCBI Synonym Full Names:	NLR family pyrin domain containing 4
NCBI Official Symbol:	NLRP4
NCBI Official Synonym Symbols:	CT58; PAN2; RNH2; NALP4; PYPAF4; CLR19.5
NCBI Protein Information:	NACHT, LRR and PYD domains-containing protein 4
UniProt Protein Name:	NACHT, LRR and PYD domains-containing protein 4
UniProt Synonym Protein Names:	Cancer/testis antigen 58; CT58; PAAD and NACHT-containing protein 2; PAN2; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; PYPAF4; Ribonuclease inhibitor 2
Protein Family:	NACHT, LRR and PYD domains-containing protein
UniProt Gene Name:	NLRP4
UniProt Entry Name:	NALP4_HUMAN