Name: NKX2-6 Antibody (PACO22379)
SKU: PACO22379
Availability: OutOfStock

Antibody Name:	NKX2-6 Antibody (PACO22379)
Antibody SKU:	PACO22379
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:	Human
Immunogen:	Synthesized peptide derived from internal of human NKX26.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western blot analysis of extracts from HeLa cells and COLO cells, using NKX26 antibody.

Background:	In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development By similarity.
Synonyms:	CSX2; homeobox Nkx-2.6; NK2 transcription factor related; 6; NKX26

UniProt Protein Function:	NKX2-6: In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development. Defects in NKX2-6 may be a cause of conotruncal heart malformations (CTHM). CTHM defines a group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Belongs to the NK-2 homeobox family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 8p21.2Cellular Component: nucleusMolecular Function: transcription factor activityBiological Process: atrial cardiac muscle cell development; cell differentiation; embryonic heart tube development; gut development; hypothalamus development; negative regulation of apoptosis; pericardium development; pharyngeal system development; positive regulation of cell proliferation; tongue development; transcription, DNA-dependent; ventricular cardiac muscle cell developmentDisease: Conotruncal Heart Malformations
UniProt Protein Details:
NCBI Summary:	This gene encodes a homeobox-containing protein that belongs to the NK-2 homeobox family. This protein is a vertebrate homolog of Drosophila homeobox-containing protein called 'tinman', which has been shown to be essential for development of the heart-like dorsal vessel. In conjunction with related gene, NKX2-5, this gene may play a role in both pharyngeal and cardiac embryonic development. Mutations in this gene are associated with persistent truncus arteriosus.[provided by RefSeq, Aug 2011]
UniProt Code:	A6NCS4
NCBI GenInfo Identifier:	158513800
NCBI Gene ID:	137814
NCBI Accession:	A6NCS4.1
UniProt Secondary Accession:	A6NCS4
UniProt Related Accession:	A6NCS4
Molecular Weight:	32,121 Da
NCBI Full Name:	Homeobox protein Nkx-2.6
NCBI Synonym Full Names:	NK2 homeobox 6
NCBI Official Symbol:	NKX2-6
NCBI Official Synonym Symbols:	CSX2; CTHM; NKX2F; NKX4-2
NCBI Protein Information:	homeobox protein Nkx-2.6
UniProt Protein Name:	Homeobox protein Nkx-2.6
UniProt Synonym Protein Names:	Homeobox protein NK-2 homolog F
Protein Family:	Homeobox protein
UniProt Gene Name:	NKX2-6
UniProt Entry Name:	NKX26_HUMAN