NKX2-6 Antibody (PACO01177)
- SKU:
- PACO01177
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NKX2-6 Antibody |
| Antibody SKU: | PACO01177 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the Internal region of human Nkx-2.6. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | NKX2-6; NKX2F; Homeobox protein Nkx-2.6; Homeobox protein NK-2 homolog F |
| UniProt Protein Function: | NKX2-6: In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development. Defects in NKX2-6 may be a cause of conotruncal heart malformations (CTHM). CTHM defines a group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Belongs to the NK-2 homeobox family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 8p21.2Cellular Component: nucleusMolecular Function: transcription factor activityBiological Process: atrial cardiac muscle cell development; cell differentiation; embryonic heart tube development; gut development; hypothalamus development; negative regulation of apoptosis; pericardium development; pharyngeal system development; positive regulation of cell proliferation; tongue development; transcription, DNA-dependent; ventricular cardiac muscle cell developmentDisease: Conotruncal Heart Malformations |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a homeobox-containing protein that belongs to the NK-2 homeobox family. This protein is a vertebrate homolog of Drosophila homeobox-containing protein called 'tinman', which has been shown to be essential for development of the heart-like dorsal vessel. In conjunction with related gene, NKX2-5, this gene may play a role in both pharyngeal and cardiac embryonic development. Mutations in this gene are associated with persistent truncus arteriosus.[provided by RefSeq, Aug 2011] |
| UniProt Code: | A6NCS4 |
| NCBI GenInfo Identifier: | 158513800 |
| NCBI Gene ID: | 137814 |
| NCBI Accession: | A6NCS4.1 |
| UniProt Secondary Accession: | A6NCS4 |
| UniProt Related Accession: | A6NCS4 |
| Molecular Weight: | 32,121 Da |
| NCBI Full Name: | Homeobox protein Nkx-2.6 |
| NCBI Synonym Full Names: | NK2 homeobox 6 |
| NCBI Official Symbol: | NKX2-6 |
| NCBI Official Synonym Symbols: | CSX2; CTHM; NKX2F; NKX4-2 |
| NCBI Protein Information: | homeobox protein Nkx-2.6 |
| UniProt Protein Name: | Homeobox protein Nkx-2.6 |
| UniProt Synonym Protein Names: | Homeobox protein NK-2 homolog F |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | NKX2-6 |
| UniProt Entry Name: | NKX26_HUMAN |
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