NKX2-5 Polyclonal Antibody
- SKU:
- CAB21992
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | NKX2-5 Polyclonal Antibody |
| Product Code: | CAB21992 |
| Reactivity: | Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse heart, Rat heart |
| Cellular Location: | Nucleus |
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-137 of human NKX2-5 (NP_004378.1). |
| Sequence: | QRSLA AAGEL SARLE ATLAP SSCML AAFKP EAYAG PEAAA PGLPE LRAEL GRAPS PAKCA SAFPA APAFY PRAYS DPDPA KDPRA EKKEL CALQK AVELE KTEAD NAERP RARR |
| Synonyms: | CSX, CSX1, VSD3, CHNG5, HLHS2, NKX2E, NKX2.5, NKX4-1 |
| Calculated MW: | 35kDa |
| Observed MW: | 30-42kDa |
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