Antibody Name:	Nkx2-2 Antibody (PACO28574)
Antibody SKU:	PACO28574
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Mouse
Immunogen:	Recombinant Mouse Homeobox protein Nkx-2.2 protein (1-273AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:

Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter.

Synonyms:

Homeobox protein Nkx-2.2 (Homeobox protein NK-2 homolog B), Nkx2-2, Nkx-2.2 Nkx2b

UniProt Protein Function:	NKX2-2: Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. Belongs to the NK-2 homeobox family.Protein type: Cell development/differentiation; Transcription factorCellular Component: intracellular; nucleusMolecular Function: chromatin binding; DNA binding; protein binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; transcription factor bindingBiological Process: astrocyte differentiation; cell development; cell differentiation; endocrine pancreas development; gut development; multicellular organismal development; negative regulation of neuron differentiation; nervous system development; neuron fate specification; oligodendrocyte development; positive regulation of cell differentiation; positive regulation of neuron differentiation; positive regulation of oligodendrocyte differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of cell differentiation; regulation of transcription, DNA-dependent; smoothened signaling pathway; spinal cord motor neuron differentiation; spinal cord oligodendrocyte cell differentiation; spinal cord oligodendrocyte cell fate specification; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
UniProt Code:	P42586
NCBI GenInfo Identifier:	6754860
NCBI Gene ID:	18088
NCBI Accession:	NP_035049.1
UniProt Secondary Accession:	P42586
UniProt Related Accession:	P42586
Molecular Weight:	46.1 kDa
NCBI Full Name:	homeobox protein Nkx-2.2 isoform 1
NCBI Synonym Full Names:	NK2 homeobox 2
NCBI Official Symbol:	Nkx2-2
NCBI Official Synonym Symbols:	Nkx2.2; tinman; Nkx-2.2
NCBI Protein Information:	homeobox protein Nkx-2.2
UniProt Protein Name:	Homeobox protein Nkx-2.2
UniProt Synonym Protein Names:	Homeobox protein NK-2 homolog B
Protein Family:	Homeobox protein
UniProt Gene Name:	Nkx2-2
UniProt Entry Name:	NKX22_MOUSE