NKIRAS2 Antibody (PACO41206)
- SKU:
- PACO41206
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NKIRAS2 Antibody (PACO41206) |
| Antibody SKU: | PACO41206 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human NF-kappa-B inhibitor-interacting Ras-like protein 2 protein (1-191AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO41206 at dilution of 1:100. |
| Background: | Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor β (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). |
| Synonyms: | NF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2) (κ B-Ras protein 2) (KappaB-Ras2), NKIRAS2, KBRAS2 |
| UniProt Protein Function: | NKIRAS2: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: G protein, monomeric, Ras; G protein; G protein, monomericChromosomal Location of Human Ortholog: 17q21.2 |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9NYR9 |
| NCBI GenInfo Identifier: | 74734716 |
| NCBI Gene ID: | 28511 |
| NCBI Accession: | Q9NYR9.1 |
| UniProt Secondary Accession: | Q9NYR9,Q6PK52, Q96KC7, Q9NSX1, A6NCZ5, B3KNN0, B4DNM3 |
| UniProt Related Accession: | Q9NYR9 |
| Molecular Weight: | 10,770 Da |
| NCBI Full Name: | NF-kappa-B inhibitor-interacting Ras-like protein 2 |
| NCBI Synonym Full Names: | NFKB inhibitor interacting Ras like 2 |
| NCBI Official Symbol: | NKIRAS2 |
| NCBI Official Synonym Symbols: | KBRAS2; kappaB-Ras2 |
| NCBI Protein Information: | NF-kappa-B inhibitor-interacting Ras-like protein 2 |
| UniProt Protein Name: | NF-kappa-B inhibitor-interacting Ras-like protein 2 |
| UniProt Synonym Protein Names: | I-kappa-B-interacting Ras-like protein 2; Kappa B-Ras protein 2; KappaB-Ras2 |
| Protein Family: | NF-kappa-B inhibitor-interacting Ras-like protein |
| UniProt Gene Name: | NKIRAS2 |
| UniProt Entry Name: | KBRS2_HUMAN |
| Antibodies |
| NKIRAS2 Antibody (PACO10862) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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