NIPBL Antibody (PACO50678)
- SKU:
- PACO50678
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NIPBL Antibody (PACO50678) |
| Antibody SKU: | PACO50678 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Nipped-B-like protein (2523-2697AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO50678 at dilution of 1:100. |
 | Western Blot. |
| Background: | Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity). |
| Synonyms: | Nipped-B-like protein (Delangin) (SCC2 homolog), NIPBL, IDN3 SCC2 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6KC79 |
| NCBI GenInfo Identifier: | 21708154 |
| NCBI Gene ID: | 25836 |
| NCBI Accession: | BC033847 |
| UniProt Secondary Accession: | Q6KC79,Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3 Q9Y6Y4 |
| UniProt Related Accession: | Q6KC79 |
| Molecular Weight: | 122,367 Da |
| NCBI Full Name: | Homo sapiens Nipped-B homolog (Drosophila), mRNA |
| NCBI Synonym Full Names: | NIPBL, cohesin loading factor |
| NCBI Official Symbol: | NIPBL |
| NCBI Official Synonym Symbols: | CDLS; IDN3; Scc2; CDLS1; IDN3-B |
| NCBI Protein Information: | nipped-B-like protein |
| UniProt Protein Name: | |
| UniProt Synonym Protein Names: | |
| Protein Family: | Nipped-B-like protein |
| UniProt Gene Name: | |
| UniProt Entry Name: |
| Antibodies |
| NIPBL Antibody (PACO10855) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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