NFKBID Antibody (PACO13939)
- SKU:
- PACO13939
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NFKBID Antibody (PACO13939) |
| Antibody SKU: | PACO13939 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human NFKBID |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO13939(NFKBID Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 10+12%SDS-PAGE, Lysate: 40 μg, Lane: RAW264.7 cells, Primary antibody: PACO13939(NFKBID Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO13939(NFKBID Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes.I κ BNS, the nuclear I κ B-like protein encoded by Nfkbid, is required for the development of marginal zone and peritoneal B-1 B cells and additionally required for extrafollicular antibody responses to T-independent and -dependent immunogens.I κ BNS has been identified as a member of the I κ B family of NF- κ B inhibitors, which undergoes induction upon TCR signaling. I κ BNS mediates both positive and negative gene regulation, depending on individual cell type and/or cytokine. |
| Synonyms: | nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, delta |
| UniProt Protein Function: | NFKBID: May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR- induced negative selection of thymocytes. Belongs to the NF-kappa-B inhibitor family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19q13.12 Cellular Component: nucleus Molecular Function:NF-kappaB binding Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of T cell differentiation in the thymus; negative regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response |
| UniProt Code: | Q8NI38 |
| NCBI GenInfo Identifier: | 74751323 |
| NCBI Gene ID: | 84807 |
| NCBI Accession: | Q8NI38.1 |
| UniProt Secondary Accession: | Q8NI38,Q8NI39, Q9BRG9, |
| UniProt Related Accession: | Q8NI38 |
| Molecular Weight: | 150 |
| NCBI Full Name: | NF-kappa-B inhibitor delta |
| NCBI Synonym Full Names: | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta |
| NCBI Official Symbol: | NFKBID |
| NCBI Official Synonym Symbols: | TA-NFKBH; IkappaBNS |
| NCBI Protein Information: | NF-kappa-B inhibitor delta; ikB-delta; ikappaBdelta; I-kappa-B-delta; T-cell activation NFKB-like protein |
| UniProt Protein Name: | NF-kappa-B inhibitor delta |
| UniProt Synonym Protein Names: | I-kappa-B-delta; IkB-delta; IkappaBdelta; IkappaBNS; T-cell activation NFKB-like protein; TA-NFKBH |
| Protein Family: | NF-kappa-B inhibitor |
| UniProt Gene Name: | NFKBID |
| UniProt Entry Name: | IKBD_HUMAN |
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