NF-kB p65/RelA Polyclonal Antibody (CAB22683)

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SKU:
CAB22683
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IHC
Applications:
IF

Description

Product Name:NF-kB p65/RelA Polyclonal Antibody
Product Code:CAB22683
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IHC-P, IF/ICC, ELISA
Key Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Recommended Dilution:WB 1:2000-1:10000, IHC-P 1:100-1:500, IF/ICC 1:100-1:500
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:HeLa, COS-7, NIH/3T3, Mouse lung, PC-12
Cellular Location:cytoplasm, cytosol, glutamatergic synapse, nucleoplasm, nucleus

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 450-551 of human NF-kB p65/RelA. (NP_068810.3).
Sequence:LGALL GNSTD PAVFT DLASV DNSEF QQLLN QGIPV APHTT EPMLM EYPEA ITRLV TGAQR PPDPA PAPLG APGLP NGLLS GDEDF SSIAD MDFSA LLSQI SS
Synonyms:p65, CMCU, NFKB3, AIF3BL3
Calculated MW:60kDa
Observed MW:65kDa
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