Neuropilin-1 (NRP1) Monoclonal Antibody
- SKU:
- CAB22213
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Neuropilin-1 (NRP1) Monoclonal Antibody |
| Product Code: | CAB22213 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55415 |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | A-549 |
| Cellular Location: | Cell membrane, Secreted, Single-pass type I membrane protein |
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-644 of human Neuropilin-1 (NRP1) (NP_003864.5). |
| Sequence: | FRNDK CGDTI KIESP GYLTS PGYPH SYHPS EKCEW LIQAP DPYQR IMINF NPHFD LEDRD CKYDY VEVFD GENEN GHFRG KFCGK IAPPP VVSSG PFLFI KFVSD YETHG AGFSI RYEIF KRGPE CSQNY TTPSG VIKSP GFPEK YPNSL ECTYI VFVPK MSEII LEFES FDLEP DSNPP GGMFC RYDRL EIWDG FPDVG PHIGR YCGQK TPGRI RSSSG ILSMV FYTDS AIAKE GFSAN YSVLQ SSVSE DFKCM EALGM ESGEI HSDQI TASSQ YSTNW SAERS RLNYP ENGWT PGEDS YREWI QVDLG LLRFV TAVGT QGAIS KETKK KYYVK TYKID VSSNG EDWIT IKEGN KPVLF QGNTN PTDVV VAVFP KPLIT RFVRI KPATW ETGIS MRFEV YGCKI TDYPC SGMLG MVSGL ISDSQ ITSSN QGDRN WMPEN IRLVT SRSGW ALPPA PHSYI NEWLQ IDLGE EKIVR GIIIQ GGKHR ENKVF MRKFK IGYSN NGSDW KMIMD DSKRK AKSFE GNNNY DTPEL RTFPA LSTRF IRIYP ERATH GGLGL RMELL GCEVE APTAG PTTPN GNLVD ECDDD QANCH SGTGD DFQLT GGTTV LATEK PTVID STIQS EFP |
| Synonyms: | NP1, NRP, BDCA4, CD304, VEGF165R |
| Calculated MW: | 68kDa/71kDa/103kDa |
| Observed MW: | 120-135kDa |
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