Nephrin Monoclonal Antibody
- SKU:
- CAB23180
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | Nephrin Monoclonal Antibody |
| Product Code: | CAB23180 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC59568 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | A-549, Jurkat, Mouse liver |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1019-1241 of human Nephrin(NP_004637.1) |
| Sequence: | GDSGL ADKGT QLPIT TPGLH QPSGE PEDQL PTEPP SGPSG LPLLP VLFAL GGLLL LSNAS CVGGV LWQRR LRRLA EGISE KTEAG SEEDR VRNEY EESQW TGERD TQSST VSTTE AEPYY RSLRD FSPQL PPTQE EVSYS RGFTG EDEDM AFPGH LYDEV ERTYP PSGAW GPLYD EVQMG PWDLH WPEDT YQDPR GIYDQ VAGDL DTLEP DSLPF ELRGH LV |
| Synonyms: | CNF, NPHN, nephrin |
| Calculated MW: | 135kDa |
| Observed MW: | 202kDa |
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