NENF Antibody (PACO63527)
- SKU:
- PACO63527
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NENF Antibody (PACO63527) |
| Antibody SKU: | PACO63527 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Peptide sequence from Human Neudesin protein (149-167AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO63527 diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO63527 diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis. |
| Synonyms: | Neudesin (Cell immortalization-related protein 2) (Neuron-derived neurotrophic factor) (Protein GIG47) (Secreted protein of unknown function) (SPUF protein), NENF, CIR2 SPUF |
| UniProt Protein Function: | NENF: Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme. Belongs to the cytochrome b5 family. MAPR subfamily.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 1q32.3Cellular Component: endomembrane system; extracellular space; membraneMolecular Function: growth factor activity; metal ion bindingBiological Process: negative regulation of appetite; positive regulation of MAPK cascade |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2009] |
| UniProt Code: | Q9UMX5 |
| NCBI GenInfo Identifier: | 7019545 |
| NCBI Gene ID: | 29937 |
| NCBI Accession: | NP_037481.1 |
| UniProt Secondary Accession: | Q9UMX5,Q53FZ6, Q5TM90, A1KYQ8 |
| UniProt Related Accession: | Q9UMX5 |
| Molecular Weight: | 18,856 Da |
| NCBI Full Name: | neudesin |
| NCBI Synonym Full Names: | neudesin neurotrophic factor |
| NCBI Official Symbol: | NENF |
| NCBI Official Synonym Symbols: | CIR2; SPUF; SCIRP10 |
| NCBI Protein Information: | neudesin |
| UniProt Protein Name: | Neudesin |
| UniProt Synonym Protein Names: | Cell immortalization-related protein 2; Neuron-derived neurotrophic factor; Protein GIG47 |
| Protein Family: | Neudesin |
| UniProt Gene Name: | NENF |
| UniProt Entry Name: |
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