NELFA Polyclonal Antibody
- SKU:
- CAB4186
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | NELFA Polyclonal Antibody |
| Product Code: | CAB4186 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Nucleus |
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-539 of human NELFA (NP_005654.3). |
| Sequence: | EETVV ENATP DYAAG LVSTQ KLGSL NNEPA LPSTS YLPST PSVVP ASSYI PSSET PPAPS SREAS RPPEE PSAPS PTLPA QFKQR APMYN SGLSP ATPTP AAPTS PLTPT TPPAV APTTQ TPPVA MVAPQ TQAPA QQQPK KNLSL TREQM FAAQE MFKTA NKVTR PEKAL ILGFM AGSRE NPCQE QGDVI QIKLS EHTED LPKAD GQGST TMLVD TVFEM NYATG QWTRF KKYKP MTNVS |
| Synonyms: | WHSC2, NELF-A, P/OKcl.15 |
| Calculated MW: | 57kDa |
| Observed MW: | Refer to figures |
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