NEK11 Antibody (PACO39162)
- SKU:
- PACO39162
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NEK11 Antibody (PACO39162) |
| Antibody SKU: | PACO39162 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Serine/threonine-protein kinase Nek11 protein (245-482AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: NEK11 antibody at 7µg/ml + Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 75, 55, 56, 69 kDa. Observed band size: 75 kDa. |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO39162 at dilution of 1:100. |
| Background: | Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. |
| Synonyms: | Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11), NEK11 |
| UniProt Protein Function: | NEK11: Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. Interacts with isoform 1 of NEK2. Poorly expressed in cerebellum, trachea, lung, appendix, and uterus. Autorepressed by intramolecular binding of the C-terminus which dissociates following phosphorylation by NEK2 isoform 1 in G1/S-arrested cells. NEK2 isoform 2 is largely not present in the nucleolus, and does not appear to phosphorylate NEK11. Activated in response to DNA damage. Inhibited by zinc. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Nucleolus; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; NEK familyChromosomal Location of Human Ortholog: 3q22.1Cellular Component: nucleolus; nucleoplasmMolecular Function: ATP binding; protein binding; protein serine/threonine kinase activityBiological Process: G2/M transition DNA damage checkpoint; histone phosphorylation; intra-S DNA damage checkpoint; protein amino acid phosphorylation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009] |
| UniProt Code: | Q8NG66 |
| NCBI GenInfo Identifier: | 313104142 |
| NCBI Gene ID: | 79858 |
| NCBI Accession: | Q8NG66.2 |
| UniProt Secondary Accession: | Q8NG66,Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4, A6NHD7 |
| UniProt Related Accession: | Q8NG66 |
| Molecular Weight: | 68,880 Da |
| NCBI Full Name: | Serine/threonine-protein kinase Nek11 |
| NCBI Synonym Full Names: | NIMA related kinase 11 |
| NCBI Official Symbol: | NEK11 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | serine/threonine-protein kinase Nek11 |
| UniProt Protein Name: | Serine/threonine-protein kinase Nek11 |
| UniProt Synonym Protein Names: | Never in mitosis A-related kinase 11; NimA-related protein kinase 11 |
| Protein Family: | |
| UniProt Gene Name: | NEK11 |
| UniProt Entry Name: | NEK11_HUMAN |
| Antibodies |
| NEK11 Antibody (PACO10814) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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