NEK10 Antibody (PACO19211)
- SKU:
- PACO19211
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NEK10 Antibody (PACO19211) |
| Antibody SKU: | PACO19211 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human NEK10 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19211(NEK10 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Nek10 (NIMA (never in mitosis gene a)-related kinase 10) is a 712 amino acid, protein belonging to the NIMA subfamily of kinases and functions as a magnesium-dependent serine/threonine protein kinase. Kinases of the NIMA subfamily are typically involved in genotoxic stress response and DNA replication. Nek10 is expressed in brain and may contain a 14-3-3 interaction motif in its C-terminus. The gene encoding Nek10 has been localized to a region on chromosome 3 that may contribute to vulnerability to addictions. Due to alternative splicing events, three isoforms exist for Nek10. |
| Synonyms: | NIMA-related kinase 10 |
| UniProt Protein Function: | NEK10: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. 7 isoforms of the human protein are produced by alternative splicing.Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Other group; NEK familyChromosomal Location of Human Ortholog: 3p24.1Cellular Component: centrosome; cytoplasm; nucleusMolecular Function: protein kinase activityBiological Process: chromosome segregation; microtubule-based process; positive regulation of MAP kinase activity; positive regulation of protein amino acid autophosphorylation; protein amino acid phosphorylation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q6ZWH5 |
| NCBI GenInfo Identifier: | 380865464 |
| NCBI Gene ID: | 152110 |
| NCBI Accession: | Q6ZWH5.3 |
| UniProt Secondary Accession: | Q6ZWH5,Q45VJ4, Q6ZR11, Q7Z671, Q86XB1, Q96MB3, A8MWG1 B9ZVR0 |
| UniProt Related Accession: | Q6ZWH5 |
| Molecular Weight: | 47,765 Da |
| NCBI Full Name: | Serine/threonine-protein kinase Nek10 |
| NCBI Synonym Full Names: | NIMA related kinase 10 |
| NCBI Official Symbol: | NEK10 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | serine/threonine-protein kinase Nek10 |
| UniProt Protein Name: | Serine/threonine-protein kinase Nek10 |
| UniProt Synonym Protein Names: | Never in mitosis A-related kinase 10; NimA-related protein kinase 10 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | NEK10 |
| UniProt Entry Name: | NEK10_HUMAN |
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