NEIL2 Polyclonal Antibody
- SKU:
- CAB8603
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | NEIL2 Polyclonal Antibody |
| Product Code: | CAB8603 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Nucleus |
This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-332 of human NEIL2 (NP_659480.1). |
| Sequence: | MPEGP LVRKF HHLVS PFVGQ QVVKT GGSSK KLQPA SLQSL WLQDT QVHGK KLFLR FDLDE EMGPP GSSPT PEPPQ KEVQK EGAAD PKQVG EPSGQ KTLDG SSRSA ELVPQ GEDDS EYLER DAPAG DAGRW LRVSF GLFGS VWVND FSRAK KANKR GDWRD PSPRL VLHFG GGGFL AFYNC QLSWS SSPVV TPTCD ILSEK FHRGQ ALEAL GQAQP VCYTL LDQRY FSGLG NIIKN EALYR AGIHP LSLGS VLSAS RREVL VDHVV EFSTA WLQGK FQGRP QHTQV YQKEQ CPAGH QVMKE AFGPE DGLQR LTWWC PQCQP QLSEE PEQCQ FS |
| Synonyms: | NEH2, NEI2 |
| Calculated MW: | 37kDa |
| Observed MW: | Refer to figures |
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