NDUFV1 Monoclonal Antibody
- SKU:
- CAB23165
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | NDUFV1 Monoclonal Antibody |
| Product Code: | CAB23165 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57616 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:2000-1:20000, IHC-P 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | SH-SY5Y, Mouse heart, Mouse kidney, Rat thymus, Rat uterus |
| Cellular Location: | Matrix side, Mitochondrion inner membrane, Peripheral membrane protein |
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10, 000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 72-420 of human NDUFV1 (NP_009034.2). |
| Sequence: | GPDWI LGEIK TSGLR GRGGA GFPTG LKWSF MNKPS DGRPK YLVVN ADEGE PGTCK DREIL RHDPH KLLEG CLVGG RAMGA RAAYI YIRGE FYNEA SNLQV AIREA YEAGL IGKNA CGSGY DFDVF VVRGA GAYIC GEETA LIESI EGKQG KPRLK PPFPA DVGVF GCPTT VANVE TVAVS PTICR RGGTW FAGFG RERNS GTKLF NISGH VNHPC TVEEE MSVPL KELIE KHAGG VTGGW DNLLA VIPGG SSTPL IPKSV CETVL MDFDA LVQAQ TGLGT AAVIV MDRST DIVKA IARLI EFYKH ESCGQ CTPCR EGVDW MNKVM ARFVR GDARP AEIDS LWEIS KQIE |
| Synonyms: | UQOR1, CI-51K, CI51KD, MC1DN4 |
| Calculated MW: | 51kDa |
| Observed MW: | 51kDa |
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