NCLN Antibody (PACO63831)
- SKU:
- PACO63831
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NCLN Antibody (PACO63831) |
| Antibody SKU: | PACO63831 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Nicalin protein (214-522AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO63831 diluted at 1:100 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. |
| Synonyms: | Nicalin (Nicastrin-like protein), NCLN |
| UniProt Protein Function: | NCLN: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Belongs to the nicastrin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 19p13.3Cellular Component: endoplasmic reticulum membrane; membrane; integral to membraneMolecular Function: protein bindingBiological Process: regulation of signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q969V3 |
| NCBI GenInfo Identifier: | 51873031 |
| NCBI Gene ID: | 56926 |
| NCBI Accession: | NP_064555.2 |
| UniProt Secondary Accession: | Q969V3,O75252, Q6FI60, Q6ZMB7, Q8TAT7, Q96H48, Q96IS7 Q9BQH9, Q9BTX4, Q9NPP2 |
| UniProt Related Accession: | Q969V3 |
| Molecular Weight: | 62,974 Da |
| NCBI Full Name: | nicalin |
| NCBI Synonym Full Names: | nicalin |
| NCBI Official Symbol: | NCLN |
| NCBI Official Synonym Symbols: | NET59 |
| NCBI Protein Information: | nicalin; nicastrin-like protein; nicalin homolog (zebrefish) |
| UniProt Protein Name: | Nicalin |
| UniProt Synonym Protein Names: | Nicastrin-like protein |
| Protein Family: | Nicalin |
| UniProt Gene Name: | NCLN |
| UniProt Entry Name: | NCLN_HUMAN |
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