| UniProt Protein Function: | NBL1 iso2: Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process. Belongs to the DAN family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Tumor suppressor; Secreted Chromosomal Location of Human Ortholog: 1p36.13 Cellular Component: extracellular space Molecular Function:morphogen activity; protein homodimerization activity Biological Process: nervous system development; determination of dorsal identity; positive regulation of neuron differentiation; neurite morphogenesis; negative regulation of BMP signaling pathway |
| NCBI Summary: | This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013] |
| UniProt Code: | P41271 |
| NCBI GenInfo Identifier: | 323276675 |
| NCBI Gene ID: | 4681 |
| NCBI Accession: | NP_001191013.1 |
| UniProt Secondary Accession: | P41271,Q5TGZ2, Q5U0N4, Q96L68, A3KFI7, |
| UniProt Related Accession: | P41271 |
| Molecular Weight: | 19,277 Da |
| NCBI Full Name: | neuroblastoma suppressor of tumorigenicity 1 isoform 2 |
| NCBI Synonym Full Names: | neuroblastoma 1, DAN family BMP antagonist |
| NCBI Official Symbol: | NBL1 |
| NCBI Official Synonym Symbols: | NB; DAN; NO3; DAND1; D1S1733E |
| NCBI Protein Information: | neuroblastoma suppressor of tumorigenicity 1; DAN domain family member 1; differential screening-selected gene aberrant in neuroblastoma; neuroblastoma candidate region, suppression of tumorigenicity 1 |
| UniProt Protein Name: | Neuroblastoma suppressor of tumorigenicity 1 |
| UniProt Synonym Protein Names: | DAN domain family member 1; Protein N03; Zinc finger protein DAN |
| Protein Family: | D-aminoacylase |
| UniProt Gene Name: | NBL1 |
| UniProt Entry Name: | NBL1_HUMAN |
![NBL1 Monoclonal Antibody [PAT38G8AT] (CPAB0590)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/58810/63992/nbl1-monoclonal-antibody-pat38g8at-cpab0590__37817__81564.1706535225.jpg?c=1 "NBL1 Monoclonal Antibody [PAT38G8AT] (CPAB0590)")
