NANOS1 Antibody (PACO52598)
- SKU:
- PACO52598
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NANOS1 Antibody (PACO52598) |
| Antibody SKU: | PACO52598 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Nanos homolog 1 protein (1-292AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of Hela cells using PACO52598 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. |
| Synonyms: | Nanos homolog 1 (NOS-1) (EC_Rep1a), NANOS1, NOS1 |
| UniProt Protein Function: | NANOS1: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. Belongs to the nanos family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 10q26.11Cellular Component: perinuclear region of cytoplasm; cytoplasmMolecular Function: protein binding; translation repressor activity; zinc ion binding; RNA bindingBiological Process: cell migration; negative regulation of translationDisease: Spermatogenic Failure 12 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q8WY41 |
| NCBI GenInfo Identifier: | 41688589 |
| NCBI Gene ID: | 340719 |
| NCBI Accession: | Q8WY41.2 |
| UniProt Secondary Accession: | Q8WY41 |
| UniProt Related Accession: | Q8WY41 |
| Molecular Weight: | 30,230 Da |
| NCBI Full Name: | Nanos homolog 1 |
| NCBI Synonym Full Names: | nanos homolog 1 (Drosophila) |
| NCBI Official Symbol: | NANOS1 |
| NCBI Official Synonym Symbols: | NOS1; SPGF12 |
| NCBI Protein Information: | nanos homolog 1; NOS-1; EC_Rep1a |
| UniProt Protein Name: | Nanos homolog 1 |
| UniProt Synonym Protein Names: | EC_Rep1a |
| Protein Family: | Nitric oxide synthase |
| UniProt Gene Name: | NANOS1 |
| UniProt Entry Name: | NANO1_HUMAN |
| Antibodies |
| NANOS1 Antibody (PACO07274) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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