NANOS1 Antibody (PACO07274)
- SKU:
- PACO07274
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NANOS1 Antibody (PACO07274) |
| Antibody SKU: | PACO07274 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:10000-1:20000, WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from Nanos Homologue 1 (NANOS1) at AA range: 151-200 |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of various cells using Antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000. |
 | Immunohistochemical analysis of paraffin-embedded human-breast-cancer, antibody was diluted at 1:200. |
 | Western Blot analysis of 3T3 cells using Nanos Homologue 1 (NANOS1) Polyclonal Antibody diluted at 1:1500. Secondary antibody was diluted at 1:20000. |
| Synonyms: | Nanos homolog 1 (NOS-1) (EC_Rep1a) |
| UniProt Protein Function: | NANOS1: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. Belongs to the nanos family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 10q26.11Cellular Component: perinuclear region of cytoplasm; cytoplasmMolecular Function: protein binding; translation repressor activity; zinc ion binding; RNA bindingBiological Process: cell migration; negative regulation of translationDisease: Spermatogenic Failure 12 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q8WY41 |
| NCBI GenInfo Identifier: | 41688589 |
| NCBI Gene ID: | 340719 |
| NCBI Accession: | Q8WY41.2 |
| UniProt Secondary Accession: | Q8WY41 |
| UniProt Related Accession: | Q8WY41 |
| Molecular Weight: | 30,230 Da |
| NCBI Full Name: | Nanos homolog 1 |
| NCBI Synonym Full Names: | nanos homolog 1 (Drosophila) |
| NCBI Official Symbol: | NANOS1 |
| NCBI Official Synonym Symbols: | NOS1; SPGF12 |
| NCBI Protein Information: | nanos homolog 1; NOS-1; EC_Rep1a |
| UniProt Protein Name: | Nanos homolog 1 |
| UniProt Synonym Protein Names: | EC_Rep1a |
| Protein Family: | Nitric oxide synthase |
| UniProt Gene Name: | NANOS1 |
| UniProt Entry Name: | NANO1_HUMAN |
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