Nampt Antibody (PACO64323)
- SKU:
- PACO64323
- Product Type:
- Antibody
- Reactivity:
- Rat
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Nampt Antibody (PACO64323) |
| Antibody SKU: | PACO64323 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:1000-1:5000 |
| Species Reactivity: | Rat, Human |
| Immunogen: | Recombinant Rat Nampt protein (231-491AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Antigen Affinity purified & Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat Heart tissue, Rat Liver tissue, Rat Spleen tissue, Rat Kidney tissue, Rat Brain tissue, Hela whole cell lysate. All lanes: Nampt antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 56 kDa. Observed band size: 56 kDa. |
| Background: | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. |
| Synonyms: | Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1 homolog) (PBEF) (Visfatin), Nampt, Pbef1 |
| UniProt Protein Function: | Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. |
| NCBI Summary: | has similarity to cytokines but is not secreted; localized to the nucleus and cytoplasm, changes in subcellular localization may be associated with the cell cycle [RGD, Feb 2006] |
| UniProt Code: | Q80Z29 |
| NCBI GenInfo Identifier: | 29293813 |
| NCBI Gene ID: | 297508 |
| NCBI Accession: | NP_808789.1 |
| UniProt Secondary Accession: | Q80Z29,Q2VT47, |
| UniProt Related Accession: | Q80Z29 |
| Molecular Weight: | 55,438 Da |
| NCBI Full Name: | nicotinamide phosphoribosyltransferase |
| NCBI Synonym Full Names: | nicotinamide phosphoribosyltransferase |
| NCBI Official Symbol: | Nampt |
| NCBI Official Synonym Symbols: | Pbef; Pbef1 |
| NCBI Protein Information: | nicotinamide phosphoribosyltransferase |
| UniProt Protein Name: | Nicotinamide phosphoribosyltransferase |
| UniProt Synonym Protein Names: | Pre-B-cell colony-enhancing factor 1 homolog; PBEF; Visfatin |
| UniProt Gene Name: | Nampt |
| ELISA Kits |
| Rat VF (Visfatin) CLIA Kit (RTES00593) |
| Rat Nicotinamide phosphoribosyltransferase (Nampt) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
PBEF/Visfatin/NAMPT Monoclonal Antibody
OverviewProduct Name:PBEF/Visfatin/NAMPT Monoclonal AntibodyProduct Code:CAB22044Reactivity:Human, Mouse, RatApplications:Western
Human PBEF/NAMPT Recombinant Protein (RPES0421)
Cell Biology Recombinant Proteins
system_update_altDatasheetHuman PBEF/NAMPT Recombinant Protein Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differen
