NALCN Antibody (PACO46798)
- SKU:
- PACO46798
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NALCN Antibody (PACO46798) |
| Antibody SKU: | PACO46798 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Sodium leak channel non-selective protein (19-141AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of HepG2 cells using PACO46798 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival (By similarity). |
| Synonyms: | Sodium leak channel non-selective protein (CanIon) (Voltage gated channel-like protein 1), NALCN, VGCNL1 |
| UniProt Protein Function: | VGCNL1: a putative voltage-gated ion channelProtein type: Membrane protein, multi-pass; Channel, calcium; Membrane protein, integral; Transporter, ion channelChromosomal Location of Human Ortholog: 13q32.3Cellular Component: plasma membrane; integral to membraneMolecular Function: voltage-gated calcium channel activity; protein binding; sodium channel activityBiological Process: sperm motility; transmembrane transportDisease: Congenital Contractures Of The Limbs And Face, Hypotonia, And Developmental Delay; Hypotonia, Infantile, With Psychomotor Retardation And Characteristic Facies |
| UniProt Protein Details: | |
| NCBI Summary: | NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007 [PubMed 17448995]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8IZF0 |
| NCBI GenInfo Identifier: | 24119274 |
| NCBI Gene ID: | 259232 |
| NCBI Accession: | NP_443099.1 |
| UniProt Secondary Accession: | Q8IZF0,Q6P2S6, Q6ZMI7, Q8IZZ1, Q8TAH1 |
| UniProt Related Accession: | Q8IZF0 |
| Molecular Weight: | 25,365 Da |
| NCBI Full Name: | sodium leak channel non-selective protein |
| NCBI Synonym Full Names: | sodium leak channel, non selective |
| NCBI Official Symbol: | NALCN |
| NCBI Official Synonym Symbols: | IHPRF; INNFD; CanIon; VGCNL1; CLIFAHDD; bA430M15.1 |
| NCBI Protein Information: | sodium leak channel non-selective protein |
| UniProt Protein Name: | Sodium leak channel non-selective protein |
| UniProt Synonym Protein Names: | CanIon; Voltage gated channel-like protein 1 |
| Protein Family: | Sodium leak channel non-selective protein |
| UniProt Gene Name: | NALCN |
| UniProt Entry Name: | NALCN_HUMAN |
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