NACA Monoclonal Antibody
- SKU:
- CAB22165
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | NACA Monoclonal Antibody |
| Product Code: | CAB22165 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53721 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:2000-1:20000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293F, Daudi, RAW264.7, Rat thymus, Rat spleen |
| Cellular Location: | Cytoplasm, Nucleus |
This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human NACA (NP_005585.1). |
| Sequence: | MPGEA TETVP ATEQE LPQPQ AETGS GTESD SDESV PELEE QDSTQ ATTQQ AQLAA AAEID EEPVS KAKQS RSEKK ARKAM SKLGL RQVTG VTRVT IRKSK NILFV ITKPD VYKSP ASDTY IVFGE AKIED LSQQA QLAAA EKFKV QGEAV SNIQE NTQTP TVQEE SEEEE VDETG VEVKD IELVM SQANV SRAKA VRALK NNSND IVNAI MELTM |
| Synonyms: | HSD48, NACA1, skNAC, NAC-alpha |
| Calculated MW: | 23kDa |
| Observed MW: | 37kDa |
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