NABP1 Antibody (PACO39542)
- SKU:
- PACO39542
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NABP1 Antibody (PACO39542) |
| Antibody SKU: | PACO39542 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human SOSS complex subunit B2 protein (1-204AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: NABP1 antibody at 2µg/ml. Lane 1: Hela whole cell lysate. Lane 2: Jurkat whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 23, 14, 15 kDa. Observed band size: 23 kDa. |
| Background: | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. |
| Synonyms: | SOSS complex subunit B2 (Nucleic acid, binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (SOSS-B2) (Single-stranded DNA-binding protein 2) (hSSB2), NABP1, OBFC2A SSB2 |
| UniProt Protein Function: | OBFC2A: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Belongs to the SOSS-B family. SOSS-B2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: DNA-binding; DNA repair, damage; Cell cycle regulationChromosomal Location of Human Ortholog: 2q32.3Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleusMolecular Function: protein binding; RNA binding; single-stranded DNA bindingBiological Process: DNA repair; double-strand break repair via homologous recombination; mitotic cell cycle checkpoint; response to DNA damage stimulus; response to ionizing radiation |
| UniProt Protein Details: | |
| NCBI Summary: | Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008] |
| UniProt Code: | Q96AH0 |
| NCBI GenInfo Identifier: | 72534722 |
| NCBI Gene ID: | 64859 |
| NCBI Accession: | NP_001026886.1 |
| UniProt Secondary Accession: | Q96AH0,Q658Y8, Q9H5X6 |
| UniProt Related Accession: | Q96AH0 |
| Molecular Weight: | 14,677 Da |
| NCBI Full Name: | SOSS complex subunit B2 isoform 1 |
| NCBI Synonym Full Names: | nucleic acid binding protein 1 |
| NCBI Official Symbol: | NABP1 |
| NCBI Official Synonym Symbols: | SSB2; OBFC2A; SOSS-B2 |
| NCBI Protein Information: | SOSS complex subunit B2 |
| UniProt Protein Name: | SOSS complex subunit B2 |
| UniProt Synonym Protein Names: | Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; SOSS-B2; Single-stranded DNA-binding protein 2; hSSB2 |
| Protein Family: | SOSS complex |
| UniProt Gene Name: | NABP1 |
| UniProt Entry Name: | SOSB2_HUMAN |
| Antibodies |
| NABP1 Antibody (PACO10987) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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