NAAA Antibody (PACO59017)
- SKU:
- PACO59017
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | NAAA Antibody (PACO59017) |
| Antibody SKU: | PACO59017 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human N-acylethanolamine-hydrolyzing acid, amidase protein (29-199AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO59017 diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Degrades bioactive fatty acid, amides to their corresponding acid, , with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine. |
| Synonyms: | N-acylethanolamine-hydrolyzing acid, amidase (EC 3.5.1) (acid, ceramidase-like protein) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid, amidase subunit alpha; N-acylethanolamine-hydrolyzing acid, amidase subunit beta], NAAA, ASAHL PLT |
| UniProt Protein Function: | ASAHL: Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N- palmitoylethanolamine > N-myristoylethanolamine > N- lauroylethanolamine = N-stearoylethanolamine > N- arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N- lauroylsphingosine and N-palmitoylsphingosine. Belongs to the acid ceramidase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Hydrolase; EC 3.5.1.-Chromosomal Location of Human Ortholog: 4q21.1Cellular Component: cytoplasm; lysosomal lumenMolecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; transcription factor bindingBiological Process: neurotransmitter secretion |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q02083 |
| NCBI GenInfo Identifier: | 116241258 |
| NCBI Gene ID: | 27163 |
| NCBI Accession: | Q02083.3 |
| UniProt Secondary Accession: | Q02083,Q5KTF2, Q96EY2, Q9BRA8 |
| UniProt Related Accession: | Q02083 |
| Molecular Weight: | 22,020 Da |
| NCBI Full Name: | N-acylethanolamine-hydrolyzing acid amidase |
| NCBI Synonym Full Names: | N-acylethanolamine acid amidase |
| NCBI Official Symbol: | NAAA |
| NCBI Official Synonym Symbols: | PLT; ASAHL |
| NCBI Protein Information: | N-acylethanolamine-hydrolyzing acid amidase |
| UniProt Protein Name: | N-acylethanolamine-hydrolyzing acid amidase |
| UniProt Synonym Protein Names: | Acid ceramidase-like protein; N-acylsphingosine amidohydrolase-like; ASAH-like protein |
| Protein Family: | N-acylethanolamine-hydrolyzing acid amidase |
| UniProt Gene Name: | NAAA |
| UniProt Entry Name: | NAAA_HUMAN |
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