N Antibody (PACO52146)
- SKU:
- PACO52146
- Product Type:
- Antibody
- Reactivity:
- Virus
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | N Antibody (PACO52146) |
| Antibody SKU: | PACO52146 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Lassa virus |
| Immunogen: | Recombinant Lassa virus Nucleoprotein protein (1-569AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with β interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation (By similarity). |
| Synonyms: | Nucleoprotein (Nucleocapsid protein) (Protein N), N |
| UniProt Protein Function: | Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation (). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P13699 |
| NCBI GenInfo Identifier: | 23343510 |
| NCBI Gene ID: | 956584 |
| NCBI Accession: | NP_694869.1 |
| UniProt Secondary Accession: | P13699 |
| UniProt Related Accession: | P13699 |
| Molecular Weight: | |
| NCBI Full Name: | nucleoprotein |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | LASVsSgp1 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | nucleoprotein |
| UniProt Protein Name: | Nucleoprotein |
| UniProt Synonym Protein Names: | Nucleocapsid protein; Protein N |
| Protein Family: | NIP3 |
| UniProt Gene Name: | N |
| UniProt Entry Name: |
