MYSM1 Transcription Factor Activity Assay
- SKU:
- TFAB00189
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- MYSM1
- Reactivity:
- Human
Description
| Product Name: | MYSM1 Transcription Factor Activity Assay |
| Product Code: | TFAB00189 |
| Target: | MYSM1 |
| Synonyms: | Myb-like, SWIRM and MPN domain-containing protein 1 |
| Reactivity: | Human |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie MYSM1 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | MYSM1: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Belongs to the peptidase M67A family. MYSM1 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin-specific protease; EC 3.4.19.-; Protease; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 1p32.1 Cellular Component: nucleoplasm; microtubule cytoskeleton; nucleus Molecular Function:DNA binding; metallopeptidase activity; histone binding; metal ion binding; ubiquitin-specific protease activity; transcription coactivator activity; protein complex binding; chromatin binding Biological Process: chromatin remodeling; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; proteolysis |
| UniProt Code: | Q5VVJ2 |
| NCBI GenInfo Identifier: | 74756898 |
| NCBI Gene ID: | 114803 |
| NCBI Accession: | Q5VVJ2.1 |
| UniProt Secondary Accession: | Q5VVJ2,Q68DD3, Q6AI53, Q7Z3G8, Q96PX3, A8KA54, B3KX65 |
| UniProt Related Accession: | Q5VVJ2 |
| Molecular Weight: | 828 |
| NCBI Full Name: | Histone H2A deubiquitinase MYSM1 |
| NCBI Synonym Full Names: | Myb-like, SWIRM and MPN domains 1 |
| NCBI Official Symbol: | MYSM1 |
| NCBI Official Synonym Symbols: | 2ADUB; 2A-DUB |
| NCBI Protein Information: | histone H2A deubiquitinase MYSM1; myb-like, SWIRM and MPN domain-containing protein 1 |
| UniProt Protein Name: | Histone H2A deubiquitinase MYSM1 |
| UniProt Synonym Protein Names: | Myb-like, SWIRM and MPN domain-containing protein 1 |
| Protein Family: | Histone H2A deubiquitinase |
| UniProt Gene Name: | MYSM1 |
| UniProt Entry Name: | MYSM1_HUMAN |
