MYO1G Antibody (PACO46046)
- SKU:
- PACO46046
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MYO1G Antibody (PACO46046) |
| Antibody SKU: | PACO46046 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Unconventional myosin-Ig protein (209-389AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human lymph node tissue using PACO46046 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO46046 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human appendix tissue using PACO46046 at dilution of 1:100. |
| Background: | Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-γ receptor (Fc-gamma-R) phagocytosis. |
| Synonyms: | Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2 (mHag HA-2)], MYO1G, HA2 |
| UniProt Protein Function: | MYO1G: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Contractile; MotorChromosomal Location of Human Ortholog: 7p13Cellular Component: membrane; phagocytic cup; plasma membraneMolecular Function: phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate bindingBiological Process: T cell mediated immunity |
| UniProt Protein Details: | |
| NCBI Summary: | MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010] |
| UniProt Code: | B0I1T2 |
| NCBI GenInfo Identifier: | 239582755 |
| NCBI Gene ID: | 64005 |
| NCBI Accession: | NP_149043.2 |
| UniProt Secondary Accession: | B0I1T2,Q8TEI9, Q8TES2, Q96BE2, Q96RI5, Q96RI6 |
| UniProt Related Accession: | B0I1T2 |
| Molecular Weight: | |
| NCBI Full Name: | unconventional myosin-Ig |
| NCBI Synonym Full Names: | myosin IG |
| NCBI Official Symbol: | MYO1G |
| NCBI Official Synonym Symbols: | HA2; MHAG; HLA-HA2 |
| NCBI Protein Information: | unconventional myosin-Ig |
| UniProt Protein Name: | Unconventional myosin-Ig |
| UniProt Synonym Protein Names: | |
| Protein Family: | Unconventional myosin |
| UniProt Gene Name: | MYO1G |
| UniProt Entry Name: | MYO1G_HUMAN |
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