MYO15A Antibody (PACO64315)
- SKU:
- PACO64315
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MYO15A Antibody (PACO64315) |
| Antibody SKU: | PACO64315 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Unconventional myosin-XV protein (237-451AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO64315 diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. |
| Background: | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity). |
| Synonyms: | Unconventional myosin-XV (Unconventional myosin-15), MYO15A, MYO15 |
| UniProt Protein Function: | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (). |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UKN7 |
| NCBI GenInfo Identifier: | 118402590 |
| NCBI Gene ID: | 51168 |
| NCBI Accession: | NP_057323.3 |
| UniProt Secondary Accession: | Q9UKN7,B4DFC7 |
| UniProt Related Accession: | Q9UKN7 |
| Molecular Weight: | 388 |
| NCBI Full Name: | unconventional myosin-XV |
| NCBI Synonym Full Names: | myosin XVA |
| NCBI Official Symbol: | MYO15A |
| NCBI Official Synonym Symbols: | DFNB3; MYO15 |
| NCBI Protein Information: | unconventional myosin-XV |
| UniProt Protein Name: | Unconventional myosin-XV |
| UniProt Synonym Protein Names: | Unconventional myosin-15 |
| Protein Family: | |
| UniProt Gene Name: | MYO15A |
| UniProt Entry Name: |
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