Description
| Product Name: | MYH7/β-MHC Monoclonal Antibody |
| Product Code: | CAB22140 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55749 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse heart, Rat heart |
| Cellular Location: | myofibril, sarcomere, Cytoplasm |
Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing distal myopathy.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1700-1800 of human MYH7/β-MHC (NP_000248.2). |
| Sequence: | KLAEQ ELIET SERVQ LLHSQ NTSLI NQKKK MDADL SQLQT EVEEA VQECR NAEEK AKKAI TDAAM MAEEL KKEQD TSAHL ERMKK NMEQT IKDLQ HRLDE A |
| Synonyms: | CMH1, MPD1, SPMD, SPMM, CMD1S, MYHCB, CMYP7A, CMYP7B |
| Calculated MW: | 223kDa |
| Observed MW: | 220-230kDa |
