Description
| Product Name: | MyD88 Monoclonal Antibody |
| Product Code: | CAB21905 |
| Reactivity: | Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52509 |
| Reactivity: | Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:2000-1:7000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse lung, Rat lung |
| Cellular Location: | Cytoplasm |
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MyD88 (NP_002459.3). |
| Sequence: | LAEEM DFEYL EIRQL ETQAD PTGRL LDAWQ GRPGA SVGRL LELLT KLGRD DVLLE LGPSI EEDCQ KYILK QQQEE AEKPL QVAAV DSSVP RTAEL AGITT L |
| Synonyms: | WM1, IMD68, MYD88D |
| Calculated MW: | 33kDa |
| Observed MW: | 33kDa |