Antibody Name:	MX2 Antibody (PACO22756)
Antibody SKU:	PACO22756
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:	Human
Immunogen:	Synthesized peptide derived from Internal of human MX2.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western blot analysis of extracts from 293 cells, using MX2 antibody.

Background:

Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.

Synonyms:

Interferon-induced GTP-binding protein Mx2; Interferon-regulated resistance GTP-binding protein MxB; MX2; MXB; myxovirus (influenza virus) resistance 2 (mouse)

UniProt Protein Function:	MX2: has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]Protein type: G protein regulator, misc.Chromosomal Location of Human Ortholog: 21q22.3Cellular Component: cytoplasm; nuclear pore; cytosol; nucleusMolecular Function: GTPase activity; GTP bindingBiological Process: protein transport; mRNA transport; metabolic process; regulation of cell cycle; regulation of nucleocytoplasmic transport; cytokine and chemokine mediated signaling pathway; response to virus; defense response; defense response to virus
UniProt Protein Details:
NCBI Summary:	The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]
UniProt Code:	P20592
NCBI GenInfo Identifier:	11342664
NCBI Gene ID:	4600
NCBI Accession:	NP_002454.1
UniProt Secondary Accession:	P20592,B7Z5D3, D3DSI7
UniProt Related Accession:	P20592
Molecular Weight:
NCBI Full Name:	interferon-induced GTP-binding protein Mx2
NCBI Synonym Full Names:	MX dynamin-like GTPase 2
NCBI Official Symbol:	MX2
NCBI Official Synonym Symbols:	MXB
NCBI Protein Information:	interferon-induced GTP-binding protein Mx2; p78-related protein; myxovirus resistance protein 2; second interferon-induced protein p78; myxovirus (influenza virus) resistance 2; interferon-regulated resistance GTP-binding protein MXB
UniProt Protein Name:	Interferon-induced GTP-binding protein Mx2
UniProt Synonym Protein Names:	Interferon-regulated resistance GTP-binding protein MxB; Myxovirus resistance protein 2; p78-related protein
Protein Family:	Interferon-induced GTP-binding protein
UniProt Gene Name:	MX2
UniProt Entry Name:	MX2_HUMAN