Mug1 Antibody (PACO34378)
- SKU:
- PACO34378
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Mug1 Antibody (PACO34378) |
| Antibody SKU: | PACO34378 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Murinoglobulin-1 protein (700-910AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective.lysine or another nucleophilic group on the proteinase, for inhibition to be effective. |
| Synonyms: | Murinoglobulin-1 (MuG1), Mug1, Mug-1 |
| UniProt Protein Function: | Mug1: A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.Cellular Component: extracellular region; extracellular spaceMolecular Function: endopeptidase inhibitor activity; protease inhibitor activity; serine-type endopeptidase inhibitor activityBiological Process: embryo implantation; negative regulation of peptidase activity |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P28665 |
| NCBI GenInfo Identifier: | 31982171 |
| NCBI Gene ID: | 17836 |
| NCBI Accession: | NP_032671.2 |
| UniProt Secondary Accession: | P28665,Q3UNE7, Q80XE6 |
| UniProt Related Accession: | P28665 |
| Molecular Weight: | 27.0 kDa |
| NCBI Full Name: | murinoglobulin-1 |
| NCBI Synonym Full Names: | murinoglobulin 1 |
| NCBI Official Symbol: | Mug1 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | murinoglobulin-1 |
| UniProt Protein Name: | Murinoglobulin-1 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Murinoglobulin |
| UniProt Gene Name: | Mug1 |
| UniProt Entry Name: | MUG1_MOUSE |
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