MUC1 Polyclonal Antibody
- SKU:
- CAB21726
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | MUC1 Polyclonal Antibody |
| Product Code: | CAB21726 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Cellular Location: | Apical cell membrane, Cell membrane, Cytoplasm, Nucleus, Secreted, Single-pass type I membrane protein |
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MUC1 (P15941). |
| Sequence: | EKNAV SMTSS VLSSH SPGSG SSTTQ GQDVT LAPAT EPASG SAATW GQDVT SVPVT RPALG STTPP AHDVT SAPDN KPAPG STAPP AHGVT SAPDT RPAPG S |
| Synonyms: | EMA, MCD, PEM, PUM, KL-6, MAM6, MCKD, PEMT, CD227, H23AG, MCKD1, MUC-1, ADMCKD, ADTKD2, Ca15-3, ADMCKD1, CA 15-3, MUC-1/X, MUC1/ZD, MUC-1/SEC |
| Calculated MW: | 122kDa |
| Observed MW: | Refer to figures |
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