MTNR1B Antibody (PACO49782)
- SKU:
- PACO49782
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MTNR1B Antibody (PACO49782) |
| Antibody SKU: | PACO49782 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Melatonin receptor type 1B protein (1-42AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human eye tissue using PACO49782 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO49782 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO49782 at dilution of 1:100. |
| Background: | High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. |
| Synonyms: | Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor), MTNR1B |
| UniProt Protein Function: | MTNR1B: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1Chromosomal Location of Human Ortholog: 11q21-q22Cellular Component: cytosol; integral to plasma membrane; plasma membraneMolecular Function: G-protein coupled receptor activity; melatonin receptor activity; protein bindingBiological Process: camera-type eye development; cell surface receptor linked signal transduction; circadian rhythm; G-protein signaling, coupled to cyclic nucleotide second messenger; glucose homeostasis; negative regulation of cGMP metabolic process; negative regulation of insulin secretion; negative regulation of neuron apoptosis; negative regulation of transmission of nerve impulse; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of transmission of nerve impulse; positive regulation of vasodilation; reduction of cytosolic calcium ion concentration; regulation of insulin secretion; synaptic transmissionDisease: Diabetes Mellitus, Noninsulin-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49286 |
| NCBI GenInfo Identifier: | 1346548 |
| NCBI Gene ID: | 4544 |
| NCBI Accession: | P49286.1 |
| UniProt Secondary Accession: | P49286 |
| UniProt Related Accession: | P49286 |
| Molecular Weight: | 40,188 Da |
| NCBI Full Name: | Melatonin receptor type 1B |
| NCBI Synonym Full Names: | melatonin receptor 1B |
| NCBI Official Symbol: | MTNR1B |
| NCBI Official Synonym Symbols: | MT2; FGQTL2; MEL-1B-R |
| NCBI Protein Information: | melatonin receptor type 1B |
| UniProt Protein Name: | Melatonin receptor type 1B |
| UniProt Synonym Protein Names: | |
| Protein Family: | Melatonin receptor |
| UniProt Gene Name: | MTNR1B |
| UniProt Entry Name: | MTR1B_HUMAN |
| Antibodies |
| MTNR1B Antibody (PACO06633) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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