MTMR7 Antibody (PACO42582)
- SKU:
- PACO42582
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MTMR7 Antibody (PACO42582) |
| Antibody SKU: | PACO42582 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Myotubularin-related protein 7 protein (1-660AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: MTMR7 antibody at 2µg/ml + Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 76, 65 kDa. Observed band size: 76 kDa. |
| Background: | Phosphatase that acts on lipids with a phosphoinositol headgroup. |
| Synonyms: | Myotubularin-related protein 7 (EC 3.1.3.-), MTMR7 |
| UniProt Protein Function: | MTMR7: a protein of the myotubularin family. Myotubularins are a family of unique protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as physiological substrates. Myotubularins specifically dephosphorylate phosphatidylinositol 3-phosphate [PI(3)P] and phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2], generating phosphatidylinositol and phosphatidylinositol 5-phosphate [PI(5)P], respectively. PI(3)P and PI(3,5)P2 regulate membrane trafficking events through the recruitment of effector proteins containing the lipid-binding domains FYVE, PH, and ENTH. MTMR5, -9, -10, -11, -12, -13 are catalytically inactive lipid phosphatases but may mediate important protein-protein interactions. Expressed at high levels in the brain. Two alternatively spliced human isoforms have been described.Protein type: Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.-; Phosphatase, lipidChromosomal Location of Human Ortholog: 8p22Cellular Component: membrane; cytosolMolecular Function: protein tyrosine phosphatase activityBiological Process: phospholipid metabolic process; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; protein amino acid dephosphorylation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the myotubularin family of tyrosine/dual-specificity phosphatases. The encoded protein is characterized by four distinct domains that are conserved among all members of the myotubularin family: the glucosyltransferase, Rab-like GTPase activator and myotubularins domain, the Rac-induced recruitment domain, the protein tyrosine phosphatases and dual-specificity phosphatases domain and the suppressor of variegation 3-9, enhancer-of-zeste, and trithorax interaction domain. This protein dephosphorylates the target substrates phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Mar 2009] |
| UniProt Code: | Q9Y216 |
| NCBI GenInfo Identifier: | 225543474 |
| NCBI Gene ID: | 9108 |
| NCBI Accession: | BC130579 |
| UniProt Secondary Accession: | Q9Y216,Q68DX4, A1L4K9, B4DG87 |
| UniProt Related Accession: | Q9Y216 |
| Molecular Weight: | |
| NCBI Full Name: | myotubularin-related protein 7 |
| NCBI Synonym Full Names: | myotubularin related protein 7 |
| NCBI Official Symbol: | MTMR7 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | myotubularin-related protein 7 |
| UniProt Protein Name: | Myotubularin-related protein 7 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Myotubularin-related protein |
| UniProt Gene Name: | MTMR7 |
| UniProt Entry Name: | MTMR7_HUMAN |
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