MTMR12 Antibody (PACO59449)
- SKU:
- PACO59449
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MTMR12 Antibody (PACO59449) |
| Antibody SKU: | PACO59449 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Myotubularin-related protein 12 protein (188-318AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of Hela cells with PACO59449 at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location. |
| Synonyms: | Myotubularin-related protein 12 (Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit) (3-PAP) (3-phosphatase adapter protein), MTMR12, KIAA1682 PIP3AP |
| UniProt Protein Function: | MTMR12: Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffold; Protein phosphatase, tyrosine (non-receptor)Chromosomal Location of Human Ortholog: 5p13.3Cellular Component: cytoplasmMolecular Function: protein binding; phosphoric monoester hydrolase activityBiological Process: dephosphorylation |
| UniProt Protein Details: | |
| NCBI Summary: | Phosphatidylinositide 3-kinase-derived membrane-anchored phosphatidylinositides, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), regulate diverse cellular processes. The protein encoded by this gene functions as an adaptor subunit in a complex with an active PtdIns(3)P 3-phosphatase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] |
| UniProt Code: | Q9C0I1 |
| NCBI GenInfo Identifier: | 94721263 |
| NCBI Gene ID: | 54545 |
| NCBI Accession: | NP_001035536.1 |
| UniProt Secondary Accession: | Q9C0I1,Q69YJ4, Q6PFW3, Q96QU2, Q9NX27 |
| UniProt Related Accession: | Q9C0I1 |
| Molecular Weight: | 86,148 Da |
| NCBI Full Name: | myotubularin-related protein 12 isoform 1 |
| NCBI Synonym Full Names: | myotubularin related protein 12 |
| NCBI Official Symbol: | MTMR12 |
| NCBI Official Synonym Symbols: | 3-PAP; PIP3AP |
| NCBI Protein Information: | myotubularin-related protein 12; 3-phosphatase adapter protein; 3-phosphatase adapter subunit; phosphatidylinositol-3-phosphate associated protein; phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit; phosphatidylinositol-3 phosphate 3-phosphatase adapter subunit; phosphatidylinositol-3 phosphate 3-phosphatase adaptor subunit |
| UniProt Protein Name: | Myotubularin-related protein 12 |
| UniProt Synonym Protein Names: | Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit; 3-PAP; 3-phosphatase adapter protein |
| Protein Family: | Myotubularin-related protein |
| UniProt Gene Name: | MTMR12 |
| UniProt Entry Name: | MTMRC_HUMAN |
| Antibodies |
| MTMR12 Antibody (PACO10644) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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