MSH2 Polyclonal Antibody (CAB21739)
- SKU:
- CAB21739
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | MSH2 Polyclonal Antibody |
| Product Code: | CAB21739 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, OVCAR3, NIH/3T3 |
| Cellular Location: | Nucleus |
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 330-583 of human MSH2 (NP_000242.1). |
| Sequence: | LNKCK TPQGQ RLVNQ WIKQP LMDKN RIEER LNLVE AFVED AELRQ TLQED LLRRF PDLNR LAKKF QRQAA NLQDC YRLYQ GINQL PNVIQ ALEKH EGKHQ KLLLA VFVTP LTDLR SDFSK FQEMI ETTLD MDQVE NHEFL VKPSF DPNLS ELREI MNDLE KKMQS TLISA ARDLG LDPGK QIKLD SSAQF GYYFR VTCKE EKVLR NNKNF STVDI QKNGV KFTNS KLTSL NEEYT KNKTE YEEAQ DAIVK EIVN |
| Synonyms: | FCC1, COCA1, HNPCC, LCFS2, MSH-2, hMSH2, HNPCC1, LYNCH1, MMRCS2 |
| Calculated MW: | 105kDa |
| Observed MW: | 105kDa |
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