MSH2 Polyclonal Antibody (CAB21494)
- SKU:
- CAB21494
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
- Applications:
- IP
Description
| Product Name: | MSH2 Polyclonal Antibody |
| Product Code: | CAB21494 |
| Reactivity: | Human, Rat |
| Applications: | Western blotting, Immunofluorescence, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Rat |
| Tested Applications: | WB, IF/ICC, IP, ELISA |
| Key Applications: | Western blotting, Immunofluorescence, Immunoprecipitation |
| Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200, IP 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, A-549 |
| Cellular Location: | Nucleus |
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human MSH2 (NP_000242.1). |
| Sequence: | MAVQP KETLQ LESAA EVGFV RFFQG MPEKP TTTVR LFDRG DFYTA HGEDA LLAAR EVFKT QGVIK YMGPA GAKNL QSVVL SKMNF ESFVK DLLLV RQYRV EVYKN RAGNK ASKEN DWYLA YKASP GNLSQ FEDIL FGNND MSASI GVVGV KMSAV DGQRQ VGVGY VDSIQ RKLGL CEFPD NDQFS NLEAL LIQIG PKECV LPGGE TAGDM GKLRQ IIQRG GILIT ERKKA DFSTK DIYQD LNRLL KGKKG EQMNS AVLPE MENQV AVSSL SAVIK FLELL SDDSN FGQFE LTTFD FSQYM |
| Synonyms: | FCC1, COCA1, HNPCC, LCFS2, MSH-2, hMSH2, HNPCC1, LYNCH1, MMRCS2 |
| Calculated MW: | 105kDa |
| Observed MW: | 105kDa |
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